Abstract |
S-adenosyl-L-methionine (SAMe) displays anti-inflammatory as well as antalgic activity without damaging the gastrointestinal mucosa in experimental animals. In fact, carrageenin-induced edema in rats and writhings provoked in mice by phenylquinone and acetic acid are controlled by SAMe in a dose dependent manner. Since PG-like substance concentration in the inflammatory exudate decreased in SAMe-treated animals the mode of action of this compound is also discussed, in view of SAMe ability to interfere with the eicosanoid system.
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Authors | M Gualano, G Stramentinoli, F Berti |
Journal | Pharmacological research communications
(Pharmacol Res Commun)
Vol. 15
Issue 7
Pg. 683-96
(Jul 1983)
ISSN: 0031-6989 [Print] United States |
PMID | 6622514
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Arachidonic Acids
- Prostaglandins
- S-Adenosylmethionine
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Arachidonic Acids
(metabolism)
- Digestive System
(drug effects)
- Edema
(drug therapy)
- Guinea Pigs
- In Vitro Techniques
- Inflammation
(metabolism)
- Male
- Mice
- Prostaglandins
(analysis)
- Rats
- Rats, Inbred Strains
- S-Adenosylmethionine
(pharmacology)
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