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Anti-inflammatory activity of S-adenosyl-L-methionine: interference with the eicosanoid system.

Abstract
S-adenosyl-L-methionine (SAMe) displays anti-inflammatory as well as antalgic activity without damaging the gastrointestinal mucosa in experimental animals. In fact, carrageenin-induced edema in rats and writhings provoked in mice by phenylquinone and acetic acid are controlled by SAMe in a dose dependent manner. Since PG-like substance concentration in the inflammatory exudate decreased in SAMe-treated animals the mode of action of this compound is also discussed, in view of SAMe ability to interfere with the eicosanoid system.
AuthorsM Gualano, G Stramentinoli, F Berti
JournalPharmacological research communications (Pharmacol Res Commun) Vol. 15 Issue 7 Pg. 683-96 (Jul 1983) ISSN: 0031-6989 [Print] United States
PMID6622514 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Arachidonic Acids
  • Prostaglandins
  • S-Adenosylmethionine
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Arachidonic Acids (metabolism)
  • Digestive System (drug effects)
  • Edema (drug therapy)
  • Guinea Pigs
  • In Vitro Techniques
  • Inflammation (metabolism)
  • Male
  • Mice
  • Prostaglandins (analysis)
  • Rats
  • Rats, Inbred Strains
  • S-Adenosylmethionine (pharmacology)

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