Content of methylhistidines in normal and pathological human skeletal muscles.

Abstract

The content of 3-methylhistidine (3-MH) and 1-methylhistidine (1-MH) was measured in muscle biopsy specimens from 13 normal controls, 19 patients with Duchenne muscular dystrophy, 8 limb-girdle disease patients, and 23 disease controls with different forms of muscular pathology. 3-MH and 1-MH concentrations in normal human muscle did not appear to be influenced by sex, body weight, and age, at least for subjects in the 10--60 year age group examined. Skeletal muscle 1-MH levels did not significantly differ from mean control values in any of the pathologies investigated. In the patient population examined, the mean 3-MH level per unit of noncollagen protein (NCP) was significantly lower than normal in Duchenne dystrophy only, the reduction being related to disease severity. The significantly lower concentrations of 3-MH in muscle of Duchenne patients indicate the importance of measuring 3-MH in diseased muscle to obtain reliable estimates of the myofibrillar protein catabolic rate.

• Authors: E Mussini, F Cornelio, F Dworzak, L Cotellessa, L Morandi, L Colombo, G De Ponte, F Marcucci
• Journal: Muscle & nerve (Muscle Nerve) 1983 Jul-Aug Vol. 6 Issue 6 Pg. 423-9 ISSN: 0148-639X [Print] United States
• PMID: 6621612 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Methylhistidines
• Muscle Proteins
• 1-methylhistidine
• Histidine
• 3-methylhistidine

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Female
• Histidine (analogs & derivatives)
• Humans
• Infant
• Male
• Methylhistidines (metabolism)
• Middle Aged
• Muscle Proteins (metabolism)
• Muscles (metabolism)
• Muscular Atrophy (metabolism)
• Muscular Diseases (metabolism)
• Muscular Dystrophies (metabolism)