[Fundamental and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].

Abstract

Human pharmacokinetics and clinical studies of T-1982 (cefbuperazone) were carried out and the following results were obtained. Transference into pelvic cavity fluid T-1982 level in pelvic cavity fluid showed the peak level of 48.0 micrograms/ml at 30 minutes after 2 hours drip infusion of 1 g in 1 case. The concentration tended to be more sustained than that of venous blood. Clinical study T-1982 was administered to 2 cases with pelveoperitonitis, 2 cases with puerperal fever and 1 case with adnexitis at a dose of 1 g twice a day for a period of 4 or 5 days. The clinical effect was excellent in 3 and good in 2 cases. Neither side effects nor abnormalities of laboratory findings were observed.

• Authors: H Hiraike, H Takashima, T Haruta, Y Kobayashi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 36 Issue 5 Pg. 1054-60 (May 1983) ISSN: 0368-2781 [Print] Japan
• PMID: 6620556 (Publication Type: Journal Article)

Chemical References

• Cephamycins
• cefbuperazone

Topics

• Adolescent
• Adult
• Aged
• Cephamycins (metabolism, therapeutic use)
• Exudates and Transudates (analysis)
• Female
• Humans
• Infusions, Parenteral
• Kinetics
• Middle Aged
• Pelvic Inflammatory Disease (drug therapy)
• Pelvis
• Peritonitis (drug therapy)
• Pregnancy
• Puerperal Infection (drug therapy)