Abstract |
Amberlite XE-336 is a pyrolized polystyrene resin with an adsorptive spectrum similar to activated charcoal. 5 normal (group I) and 5 uremic (group II) dogs had 6 h of hemoperfusion with a 400-gram column of Amberlite XE-336 resin with a blood flow rate of 300 ml/min. In group II during 0, 0.5, 1, 3, and 6 h of hemoperfusion the mean column clearances of creatinine were 273 +/- 10, 224 +/- 7, 177 +/- 8, 125 +/- 30, and 64 +/- 17 ml/min and the serum creatinine concentration decreased from 10.4 +/- 1.3 to 3.2 +/- 0.9 mg/dl. In one of the uremic dogs the column clearance of middle molecules measured at 0, 0,5, 1, 3, and 6 h of hemoperfusion was 273,258,101,109, and 23 ml/min. The side reactions in group I and II hemoperfusion studies included transient hypotension, hypocalcemia, leukopenia and a reduction in platelet count.
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Authors | J L Rosenbaum, M S Kramer, R Raja |
Journal | Nephron
(Nephron)
Vol. 21
Issue 1
Pg. 27-37
( 1978)
ISSN: 1660-8151 [Print] Switzerland |
PMID | 662054
(Publication Type: Journal Article)
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Chemical References |
- Polystyrenes
- Resins, Plant
- Toxins, Biological
- Amberlite XE-336
- Sodium
- Creatinine
- Magnesium
- Calcium
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Topics |
- Adsorption
- Animals
- Blood Platelets
- Calcium
(blood)
- Chromatography, Gel
- Creatinine
(blood)
- Dogs
- Hemoperfusion
- Leukocyte Count
- Magnesium
(blood)
- Male
- Polystyrenes
- Resins, Plant
- Sodium
(blood)
- Toxins, Biological
(blood)
- Uremia
(blood, metabolism, therapy)
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