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International clinical experience with azlocillin.

Abstract
Clinical studies with azlocillin were conducted in North America and Europe to assess its efficacy and to monitor its safety. The results of studies from these two areas are compared retrospectively. In North America 631 multiple-dose courses were monitored, while 887 were given in Europe. The most frequently administered daily dose was 18 g in North America and 15 g in Europe. In 71% of the courses a Pseudomonas species was the causative infecting organism in the former area and 51% in the latter. Over 60% of the patients were seriously ill, and about a third were over 60 years of age. A satisfactory bacteriological response, as defined by the eradication or a marked reduction of the organism causing infection was obtained in 74% of patients in North America and in 75% in Europe. 89% of the patients in America responded clinically compared to 92% in Europe. Ps. aeruginosa was eradicated in over 70% of instances. Azlocillin, like other penicillins, possesses a low potential for toxicity. Hypersensitivity reactions and gastrointestinal effects were the most common adverse experiences. No serious problems were encountered with impairment of renal or hepatic function, or blood coagulation. Azlocillin was effective for treating serious infections caused primarily by Ps. aeruginosa.
AuthorsP Schacht, G Arcieri, H Bruck, E Griffith, R Hullman, D Tettenborn
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 11 Suppl B Pg. 215-22 (May 1983) ISSN: 0305-7453 [Print] England
PMID6619030 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Penicillins
  • Azlocillin
Topics
  • Adolescent
  • Adult
  • Aged
  • Azlocillin
  • Bacterial Infections (drug therapy, microbiology)
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Middle Aged
  • Penicillins (administration & dosage, therapeutic use)
  • Respiratory Tract Infections (drug therapy)
  • Sepsis (drug therapy)
  • Urinary Tract Infections (drug therapy)

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