The complete amino acid sequence of oncomodulin--a parvalbumin-like calcium-binding protein from Morris hepatoma 5123tc.

Abstract

Oncomodulin is an acidic calcium-binding protein of 108 amino acids which has been detected only in tumors. The complete amino acid sequence of rat oncomodulin has been established, and the N-terminus shown to be N-acetylserine. Homology of the oncomodulin sequence with members of the troponin C superfamily of calcium-binding proteins was demonstrated, and putative calcium-binding domains were located. A further degree of homology was established between oncomodulin and the parvalbumins, including rat parvalbumin. Oncomodulin was therefore considered to be a parvalbumin-like calcium-binding protein.

• Authors: J P MacManus, D C Watson, M Yaguchi
• Journal: European journal of biochemistry (Eur J Biochem) Vol. 136 Issue 1 Pg. 9-17 (Oct 17 1983) ISSN: 0014-2956 [Print] England
• PMID: 6617664 (Publication Type: Journal Article)

Chemical References

• Calcium-Binding Proteins
• Neoplasm Proteins
• Parvalbumins
• Peptide Fragments
• oncomodulin

Topics

• Amino Acid Sequence
• Animals
• Calcium-Binding Proteins (isolation & purification)
• Chemical Phenomena
• Chemistry
• Liver Neoplasms, Experimental (analysis)
• Neoplasm Proteins (isolation & purification)
• Parvalbumins
• Peptide Fragments
• Rats