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[Efficacy of cimetidine in the prevention of aspiration pneumonia in paediatric anaesthesia].

Abstract
In a prospective controlled study 63% of 150 children without prophylaxis were at risk of aspiration pneumonia in case of aspiration or regurgitation. In a second trial 10 mg/kg cimetidine orally 120 to 180 minutes prior to induction of anaesthesia proved to be a very effective prophylaxis. In small children up to 15 kg rectal application of 40 mg/kg cimetidine was even more effective than 10 mg/kg orally in reducing gastric volume. Premedication with cimetidine may be a practicable method for reducing the risk of aspiration pneumonia in paediatric anaesthesia.
AuthorsM Tryba, F Yildiz, U Weissenborn, J Hausdörfer
JournalAnasthesie, Intensivtherapie, Notfallmedizin (Anasth Intensivther Notfallmed) Vol. 18 Issue 3 Pg. 116-20 (Jun 1983) ISSN: 0174-1837 [Print] Germany
Vernacular TitleWirksamkeit von Cimetidin zur Prophylaxe der Aspirationspneumonie in der Kinderanästhesie.
PMID6614410 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Guanidines
  • Cimetidine
Topics
  • Adolescent
  • Age Factors
  • Anesthesia, General
  • Child
  • Child, Preschool
  • Cimetidine (administration & dosage, therapeutic use)
  • Guanidines (therapeutic use)
  • Humans
  • Infant
  • Pneumonia, Aspiration (prevention & control)
  • Premedication
  • Prospective Studies

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