Abstract |
In a prospective controlled study 63% of 150 children without prophylaxis were at risk of aspiration pneumonia in case of aspiration or regurgitation. In a second trial 10 mg/kg cimetidine orally 120 to 180 minutes prior to induction of anaesthesia proved to be a very effective prophylaxis. In small children up to 15 kg rectal application of 40 mg/kg cimetidine was even more effective than 10 mg/kg orally in reducing gastric volume. Premedication with cimetidine may be a practicable method for reducing the risk of aspiration pneumonia in paediatric anaesthesia.
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Authors | M Tryba, F Yildiz, U Weissenborn, J Hausdörfer |
Journal | Anasthesie, Intensivtherapie, Notfallmedizin
(Anasth Intensivther Notfallmed)
Vol. 18
Issue 3
Pg. 116-20
(Jun 1983)
ISSN: 0174-1837 [Print] Germany |
Vernacular Title | Wirksamkeit von Cimetidin zur Prophylaxe der Aspirationspneumonie in der Kinderanästhesie. |
PMID | 6614410
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adolescent
- Age Factors
- Anesthesia, General
- Child
- Child, Preschool
- Cimetidine
(administration & dosage, therapeutic use)
- Guanidines
(therapeutic use)
- Humans
- Infant
- Pneumonia, Aspiration
(prevention & control)
- Premedication
- Prospective Studies
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