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[Incorporation of tritium into the DNA of hematopoietic tissues during prolonged administration of tritium oxide].

Abstract
With long-term (90 days) administration of tritium oxide (0.37 MBq/g body weight) to ras the carbon-bound tritium accumulated in DNA of haemopoietic tissues during two-month administration of the isotope (the accumulation half-time of 15-25 days); during the next month, the isotope level remained nearly constant (about 20 X 10(6) decay/min/g DNA). Elimination of tritium from DNA started 3 days after termination of its administration and proceeded with two half-times (4-8 days and 12-18 days). The ratio of the tritium content per 1 M hydrogen of DNA to tritium content per 1 M hydrogen of tissue water increased up to 0.5-0.7 during the uptake of tritium oxide, and up to 4-7 after the administration of the isotope had ceased.
AuthorsG S Mushkacheva, V V Kreslov
JournalRadiobiologiia (Radiobiologiia) 1983 Jul-Aug Vol. 23 Issue 4 Pg. 558-62 ISSN: 0033-8192 [Print] Russia (Federation)
Vernacular TitleInkorporatsiia tritiia v DNK krovetvornykh tkaneĭ pri dlitel'nom vvedenii okisi tritiia.
PMID6611889 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Water
  • Tritium
  • tritium oxide
  • DNA
Topics
  • Animals
  • Bone Marrow (metabolism)
  • DNA (metabolism)
  • Male
  • Rats
  • Spleen (metabolism)
  • Thymus Gland (metabolism)
  • Time Factors
  • Tritium (administration & dosage, metabolism)
  • Water (administration & dosage)

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