Abstract |
With long-term (90 days) administration of tritium oxide (0.37 MBq/g body weight) to ras the carbon-bound tritium accumulated in DNA of haemopoietic tissues during two-month administration of the isotope (the accumulation half-time of 15-25 days); during the next month, the isotope level remained nearly constant (about 20 X 10(6) decay/min/g DNA). Elimination of tritium from DNA started 3 days after termination of its administration and proceeded with two half-times (4-8 days and 12-18 days). The ratio of the tritium content per 1 M hydrogen of DNA to tritium content per 1 M hydrogen of tissue water increased up to 0.5-0.7 during the uptake of tritium oxide, and up to 4-7 after the administration of the isotope had ceased.
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Authors | G S Mushkacheva, V V Kreslov |
Journal | Radiobiologiia
(Radiobiologiia)
1983 Jul-Aug
Vol. 23
Issue 4
Pg. 558-62
ISSN: 0033-8192 [Print] Russia (Federation) |
Vernacular Title | Inkorporatsiia tritiia v DNK krovetvornykh tkaneĭ pri dlitel'nom vvedenii okisi tritiia. |
PMID | 6611889
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Water
- Tritium
- tritium oxide
- DNA
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Topics |
- Animals
- Bone Marrow
(metabolism)
- DNA
(metabolism)
- Male
- Rats
- Spleen
(metabolism)
- Thymus Gland
(metabolism)
- Time Factors
- Tritium
(administration & dosage, metabolism)
- Water
(administration & dosage)
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