The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man.

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in the pars compacta of the substantia nigra (A8 and A9 cells). MPTP or its metabolite enters nerve cells at the level of their terminals in the caudate nucleus and putamen leading to a disturbance in axoplasmic flow and retrograde degeneration. The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury.

• Authors: R S Burns, S P Markey, J M Phillips, C C Chiueh
• Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 11 Issue 1 Suppl Pg. 166-8 (Feb 1984) ISSN: 0317-1671 [Print] England
• PMID: 6608980 (Publication Type: Journal Article)

Chemical References

• Pyridines
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• Dopamine

Topics

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• Animals
• Biomechanical Phenomena
• Brain (drug effects)
• Dopamine (physiology)
• Humans
• Macaca fascicularis
• Macaca mulatta
• Neurons (drug effects)
• Parkinson Disease, Secondary (chemically induced)
• Pyridines (toxicity)
• Saimiri
• Substantia Nigra (drug effects)