Epiglottitis due to ampicillin-tolerant Haemophilus influenzae type b.

Abstract

Tolerance to beta-lactam antibiotics has been described with staphylococci and enterococci, but this phenomenon and its clinical significance in Haemophilus influenzae has not been reported. We have reported a case of bacteremic epiglottitis due to an ampicillin-tolerant, beta-lactamase-negative strain of Haemophilus influenzae type b which was cured with ampicillin therapy alone. The organism was not tolerant to moxalactam, cefotaxime, or rifampin. Rifampin therapy eliminated pharyngeal carriage.

• Authors: E L Westerman, J Puls, J R Medina
• Journal: Southern medical journal (South Med J) Vol. 77 Issue 3 Pg. 386-7 (Mar 1984) ISSN: 0038-4348 [Print] United States
• PMID: 6608151 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ampicillin
• Rifampin

Topics

• Ampicillin (administration & dosage, pharmacology)
• Cerebrospinal Fluid (microbiology)
• Drug Therapy, Combination
• Epiglottitis (etiology)
• Haemophilus Infections (drug therapy)
• Haemophilus influenzae (drug effects, isolation & purification)
• Humans
• Laryngitis (etiology)
• Male
• Middle Aged
• Penicillin Resistance
• Pharynx (microbiology)
• Rifampin (administration & dosage)