Malignant myositis ossificans: occult gastric carcinoma presenting as an acute rheumatic disorder.

Abstract

A patient developed ossifying skeletal muscle metastases from a primary gastric mucin-producing adenocarcinoma. The unusual nature of skeletal muscle metastases and the inflammatory-like syndrome associated with heterotopic ossification is reviewed. It is suggested that this case of 'neoplasm-induced post-traumatic myositis ossificans' may be caused by the interaction of local haemorrhage and thrombosis, mucin-producing tumour implants, and the presence of large quantities of gamma-carboxyglutamic acid, an amino acid associated with the calcification of bone matrix formation.

• Authors: L H Rosenbaum, J J Nicholas, B S Slasky, D L Obley, L D Ellis
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 43 Issue 1 Pg. 95-7 (Feb 1984) ISSN: 0003-4967 [Print] England
• PMID: 6607713 (Publication Type: Case Reports, Journal Article)

Chemical References

• 1-Carboxyglutamic Acid

Topics

• 1-Carboxyglutamic Acid (metabolism)
• Adenocarcinoma (secondary)
• Humans
• Male
• Middle Aged
• Muscles (injuries)
• Muscular Diseases (complications)
• Myositis Ossificans (etiology, metabolism)
• Rheumatic Diseases (etiology)
• Stomach Neoplasms