Efficacy of different DTPA treatment schedules for removal of 234Th from simulated wounds in rats.

Abstract

The translocation of 234Th from a simulated wound site and the efficacy of DTPA administration, as a function of the thorium compound injected as well as the DTPA treatment schedule, have been investigated in rats. Much more 234Th injected as citrate was translocated from the injection site than after administration as nitrate, whereas the distribution pattern of 234Th translocated to the various tissues was nearly identical for both 234Th compounds. Combined local and systematic treatment with DTPA was equally or more effective than each of the treatments alone in reducing the retention of 234Th at the injection site and in the organs.

• Authors: E Peter-Witt, V Volf
• Journal: International journal of radiation biology and related studies in physics, chemistry, and medicine (Int J Radiat Biol Relat Stud Phys Chem Med) Vol. 45 Issue 1 Pg. 45-9 (Jan 1984) ISSN: 0020-7616 [Print] England
• PMID: 6607231 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Citrates
• Thorium Compounds
• Citric Acid
• Thorium
• Pentetic Acid
• thorium nitrate

Topics

• Animals
• Citrates (metabolism)
• Citric Acid
• Decontamination (methods)
• Drug Administration Schedule
• Female
• Pentetic Acid (administration & dosage)
• Rats
• Thorium (metabolism)
• Thorium Compounds
• Tissue Distribution
• Wounds and Injuries (complications)