Topical protection against long-wave ultraviolet A.

Abstract

A PABA ester-oxybenzone preparation is superior to PABA or sulisobenzone alone in protecting the skin from methoxsalen-induced ultraviolet A (UVA) phototoxicity after water substantivity challenge. Such a mixture would be useful as a UVA screen for uninvolved or actinically damaged skin in patients receiving psoralens and ultraviolet A (PUVA) therapy. An effective topical UVA screen also may protect against UVA-induced diseases like solar urticaria, polymorphic light eruptions, drug-induced phototoxicity or photoallergy, and possibly against the deep degenerative changes of solar elastosis.

• Authors: M Jarratt, M Hill, K Smiles
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 9 Issue 3 Pg. 354-60 (Sep 1983) ISSN: 0190-9622 [Print] United States
• PMID: 6605370 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Benzophenones
• N,N-dimethyl-2-ethylhexyl-4-aminobenzoate
• Sunscreening Agents
• para-Aminobenzoates
• sulisobenzone
• oxybenzone
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (administration & dosage)
• Adult
• Benzophenones (administration & dosage)
• Dose-Response Relationship, Radiation
• Humans
• Male
• PUVA Therapy (adverse effects)
• Photochemotherapy (adverse effects)
• Sunburn (prevention & control)
• Sunscreening Agents (administration & dosage)
• Ultraviolet Rays (adverse effects)
• para-Aminobenzoates