Low-affinity E-rosette-blocking factor in hemodialysis-treated patients in chronic renal failure.

Abstract

Enumeration of total E-rosette-forming cells (t-ERFC) enabled 30 renal failure patients on hemodialysis to be classified into three groups: group 1 with normal numbers of t-ERFC, and groups 2A and 2B with reversibly and irreversibly reduced numbers, respectively. Duration of dialysis treatment was the only distinguishing feature between these three groups, being shorter for group 1 than for group 2A (P less than 0.02) and shorter for group 2A than for group 2B (P less than 0.001). However, a rosette-blocking factor (RBF) was demonstrated in all three groups which predominantly affected the low-affinity ERFC (i.e., total ERFC minus active ERFC). This factor could be partially absorbed (P less than 0.01) on normal lymphocytes and showed increased activity after a single dialysis session, suggesting the removal by dialysis of a putative anti-RBF substance.

• Authors: P Youinou, J Cledes, J P Herve, P Miossec, W J Morrow
• Journal: Clinical immunology and immunopathology (Clin Immunol Immunopathol) Vol. 26 Issue 3 Pg. 423-31 (Mar 1983) ISSN: 0090-1229 [Print] United States
• PMID: 6603309 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABO Blood-Group System
• Blood Proteins
• Lipoproteins, LDL
• rosette-inhibiting factor

Topics

• ABO Blood-Group System (immunology)
• Adult
• Aged
• Animals
• Blood Proteins (analysis)
• Erythrocytes (immunology)
• Female
• Humans
• Kidney Failure, Chronic (immunology, therapy)
• Lipoproteins, LDL
• Male
• Middle Aged
• Renal Dialysis
• Rosette Formation
• Sheep (immunology)
• T-Lymphocytes (immunology)
• Time Factors