[Distribution of electric charges in 2 substances inducing tumor cell regression].

Abstract

The charge distribution of anti-cancer molecules 4-thiazolidine-carboxylic acid and 2-amino-2-thiazoline hydrochloride was calculated with a CNDO/2 semiempiral quantum mechanic method. The activity seems to be related with the formation of Zn2+ and Mn2+ ions. Both molecules show local isosterism, origin of their chelating properties.

• Authors: Y G Smeyers, A Huertas
• Journal: Revista espanola de oncologia (Rev Esp Oncol) Vol. 30 Issue 4 Pg. 515-8 ( 1983) ISSN: 0482-640X [Print] Spain
• Vernacular Title: Distribución de cargas eléctricas en dos inductores de regresión en células tumorales.
• PMID: 6599915 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Thiazoles
• Thiazolidines
• 2-aminothiazoline
• thiazolidine-4-carboxylic acid

Topics

• Antineoplastic Agents
• Electrochemistry
• Thiazoles
• Thiazolidines