HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of conorphone, a mixed agonist-antagonist analgesic, to codeine for postoperative dental pain.

Abstract
The analgesic efficacy of two doses of conorphone (20 and 40 mg), a mixed agonist-antagonist analgesic, were compared to two doses of codeine for postoperative pain in the oral surgery model. Each subject received 2 of the 4 possible treatment at two separate sessions in an incomplete block, single crossover design. Both doses of conorphone and the 60 mg dose of codeine were superior to 30 mg of codeine for the various indices of analgesic activity. The 40 mg dose of conorphone resulted in a high incidence of side effects (25/30 subjects) such as drowsiness, dizziness, nausea and vomiting. The low dose of conorphone resulted in side effects similar to 60 mg of codeine with the exception of a greater incidence of drowsiness. These data suggest that while 40 mg of conorphone may not be well tolerated clinically, 20 mg of conorphone may be an alternative to 60 mg of codeine for postoperative pain.
AuthorsR A Dionne, P R Wirdezk, D P Butler, P C Fox
JournalAnesthesia progress (Anesth Prog) 1984 Mar-Apr Vol. 31 Issue 2 Pg. 77-81 ISSN: 0003-3006 [Print] United States
PMID6597688 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Hydrocodone
  • codorphone
  • Codeine
Topics
  • Adolescent
  • Adult
  • Codeine (administration & dosage, analogs & derivatives, pharmacology)
  • Female
  • Humans
  • Hydrocodone (administration & dosage, analogs & derivatives, pharmacology)
  • Male
  • Molar, Third (surgery)
  • Pain, Postoperative (drug therapy)
  • Tooth Extraction (adverse effects)
  • Tooth, Impacted (surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: