Leukemia-derived growth factor (non-interleukin-2) produced by murine lymphoma T-cell lines.

Abstract

Autocrine growth factor activity was found in supernatants of AKR T-cell lymphoma lines cultured in serum-free medium. This factor was designated leukemia-derived growth factor (LDGF). Active supernatants stimulated the growth of the AKR murine T-cell lymphoma line SL 12, its cloned derivatives, and all other murine T-cell lymphoma lines tested. Growth factor activity in conditioned medium was found to be different from interleukin 2 (IL-2) and several other known growth factors. LDGF was able to stimulate growth of the human leukemia T-cells MOLT4f, and the LDGF from MOLT4f cells stimulated the mouse cells. Because mouse T-cell lymphoma lines produced and respond to this factor, it may support the continued proliferation of these cells and could be responsible for their malignant in vivo properties.

• Authors: E F Hays, D Goodrum, M Bessho, S Kitada, C H Uittenbogaart
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 81 Issue 24 Pg. 7807-11 (Dec 1984) ISSN: 0027-8424 [Print] United States
• PMID: 6595661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Neoplasm Proteins
• Peptides
• Transforming Growth Factors

Topics

• Animals
• Cell Division (drug effects)
• Cell Line
• DNA Replication (drug effects)
• Humans
• Kinetics
• Leukemia
• Lymphoma
• Mice
• Mice, Inbred AKR
• Mice, Inbred BALB C
• Neoplasm Proteins (isolation & purification)
• Peptides (isolation & purification, pharmacology, physiology)
• Species Specificity
• Transforming Growth Factors