A test of the role of two oncogenes in inherited predisposition to colon cancer.

Abstract	Inheritance of mutationally altered oncogenes could predispose individuals to the development of specific tumors and account for familial tumor phenotypes. Using adjacent DNA sequence polymorphisms as genetic markers, we have examined two oncogenes, the Kirsten ras2, isolated from a human colon cancer cell line, and the Harvey ras1, isolated from a human bladder cancer cell line, for their role in the genetic etiology of inherited colon cancer in Gardner syndrome. Both oncogene loci have been shown to be unlinked to the Gardner syndrome locus and are, therefore, eliminated as candidates for the Gardner syndrome gene.
Authors	D Barker, M McCoy, R Weinberg, M Goldfarb, M Wigler, R Burt, E Gardner, R White
Journal	Molecular biology & medicine (Mol Biol Med) Vol. 1 Issue 2 Pg. 199-206 (Sep 1983) ISSN: 0735-1313 [Print] England
PMID	6594558 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	DNA, Neoplasm Genetic Markers
Topics	Base Sequence Colonic Neoplasms (genetics) DNA, Neoplasm (genetics) Female Gardner Syndrome (genetics) Genetic Linkage Genetic Markers Humans Male Oncogenes Pedigree Polymorphism, Genetic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!