Phenotypic changes induced by a novel benzophenone derivative and resultant suppression of cell proliferation in the human thymic acute lymphoblastic leukemia cell line HPB-ALL.

Abstract

A novel benzophenone derivative, 2-(2-benzoyl-4-chlorophenoxy)-N-methylpropionamide (Ch-13), induced phenotypic differentiation linked to the inhibition of cell proliferation in human thymic acute lymphoblastic leukemia cell line HPB-ALL cells. The Ch-13-induced morphological changes consist of a decrease in cell size, nucleolar disappearance, and an alteration in the chromatin distribution, resembling large or atypical lymphocytes. Treatment with Ch-13 brought about a remarkable reduction in OKT6-, OKT4/Leu3a-, and OKT9-positive cells. At the optimal differentiation-inducing dose (5 X 10(-5)M), Ch-13 inhibited the cell proliferation, de novo DNA synthesis, and specific antibody-induced cell surface antigen capping.

• Authors: Y Nakao, S Matsuda, T Matsui, T Nakagawa, T Koizumi, T Saida, T Fujita
• Journal: Cancer research (Cancer Res) Vol. 44 Issue 12 Pt 1 Pg. 5836-44 (Dec 1984) ISSN: 0008-5472 [Print] United States
• PMID: 6594195 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Surface
• Benzophenones
• 2-(2-benzoyl-4-chlorophenoxy)-N-methylpropionamide

Topics

• Antigens, Surface (analysis)
• Benzophenones (toxicity)
• Cell Division (drug effects)
• Cell Line
• Humans
• Kinetics
• Leukemia, Lymphoid (pathology)
• Phenotype
• Structure-Activity Relationship
• Thymus Neoplasms (pathology)