Abstract |
A new, chemically stable analogue of PGE2, 11-deoxy-13,14-didehydro-16(S)-methyl PGE2 methylester ( FCE 20700) was studied for the prevention of different gastrointestinal ulcers and for the inhibition of basal gastric acid secretion in the rat. The diarrhoea-inducing activity was also investigated. FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9.2 and 14.8 mcg/kg) and indomethacin-induced gastric ulcers (ED50 = 37.8 and 22.3 mcg/kg). FCE 20700 weakly affects gastric acid secretion with an ED50 of 2385 mcg/kg, showing clear separation of antisecretory activity and gastric antiulcer potency. FCE 20700 does not induce diarrhoea in rats at doses up to 6.25 mg/kg, 10 to 600 times the effective antiulcer doses.
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Authors | C Arrigoni, B Mizzotti, D Toti, F Faustini, R Ceserani |
Journal | Prostaglandins, leukotrienes, and medicine
(Prostaglandins Leukot Med)
Vol. 15
Issue 1
Pg. 79-89
(Jul 1984)
ISSN: 0262-1746 [Print] Scotland |
PMID | 6591214
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Prostaglandins E, Synthetic
- Ethanol
- FCE 20700
- Dinoprostone
- Indomethacin
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Topics |
- Animals
- Anti-Ulcer Agents
- Diarrhea
(chemically induced)
- Dinoprostone
(analogs & derivatives)
- Ethanol
(antagonists & inhibitors)
- Gastric Juice
(metabolism)
- Indomethacin
(antagonists & inhibitors)
- Intestines
- Male
- Peptic Ulcer
(prevention & control)
- Prostaglandins E, Synthetic
(pharmacology)
- Rats
- Secretory Rate
(drug effects)
- Stomach Ulcer
(chemically induced)
- Stress, Physiological
(complications)
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