Induction of oral mucosal tumors in hamsters and rats treated with methyl(acetoxymethyl)nitrosamine.

Abstract

An oral tumor model has been developed in inbred Syrian golden hamsters by continuous applications every 2 weeks of methyl(acetoxymethyl)nitrosamine [(DMN-OAC) CAS: 56856-83-8; methylnitrosaminomethyl ester acetic acid] at 2 mg/kg body weight alone or by a single application of DMN-OAC followed by continuous twice weekly applications of 12-O-tetradecanoylphorbol 13-acetate (TPA) (1 microgram/animal). Similar studies were done in the W rat buccal mucosa. In the hamsters treated continuously with DMN-OAC, 100% of the tumors were observed in the cheek pouch; none were observed at other sites. In contrast, in the rats treated similarly, only a 67% tumor incidence was observed, of which only 42% were oral tumors. A promoter effect of TPA was observed in hamster cheek pouch tumors induced by DMN-OAC, whereas rat oral mucosa did not respond to TPA treatment.

• Authors: S V Bhide, K M Munir, M Wiessler, A V Sarode, C S Soman
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 73 Issue 3 Pg. 737-41 (Sep 1984) ISSN: 0027-8874 [Print] United States
• PMID: 6590918 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• methyl(acetoxymethyl)nitrosamine
• Dimethylnitrosamine
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Carcinogens
• Cheek
• Cricetinae
• Dimethylnitrosamine (analogs & derivatives, toxicity)
• Mouth Mucosa (drug effects, pathology)
• Mouth Neoplasms (chemically induced, pathology)
• Rats
• Tetradecanoylphorbol Acetate