Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts.

The tissue distribution of naked and either normal immunoglobulin G or monoclonal antibody (antitumor osteogenic sarcoma)-coated poly(hexyl-2-cyanoacrylate) nanoparticles was studied in mice bearing human tumor xenografts to evaluate the applicability of the systems for tumor targeting. All systems were shown to deposit mainly in the liver and spleen and no significant uptake was found in the tumors for either the naked or antibody-coated nanoparticles.
AuthorsL Illum, P D Jones, R W Baldwin, S S Davis
JournalThe Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 230 Issue 3 Pg. 733-6 (Sep 1984) ISSN: 0022-3565 [Print] UNITED STATES
PMID6590835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Cyanoacrylates
  • Immunoglobulin G
  • poly(hexyl-2-cyanoacrylate)
  • Adsorption
  • Animals
  • Antibodies, Monoclonal (immunology)
  • Cell Line
  • Cyanoacrylates (administration & dosage, metabolism)
  • Humans
  • Immunoglobulin G (metabolism)
  • Liver (metabolism)
  • Mice
  • Neoplasm Transplantation
  • Osteosarcoma (immunology)
  • Tissue Distribution

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