Electron microscopic study of the effects of thallium poisoning on the rat cerebellum.

Abstract

Rats were given thallium acetate (5 mg elemental thallium/kg body weight) intra-peritoneally daily for 7 days. The brain was fixed by perfusion-fixation and small pieces of the cerebellum were processed for electron microscopy. Variegated mitochondrial profiles, increased incidence of electron--dense bodies and proliferation of Golgi zones were observed in the thallium--poisoned rat cerebellum. Multilamellar cytoplasmic bodies were discernible in the cerebellar cortex of the thallium-treated rats.

• Authors: M Hasan, I Ashraf, V K Bajpai
• Journal: Forensic science (Forensic Sci) 1978 Mar-Apr Vol. 11 Issue 2 Pg. 139-46 ISSN: 0300-9432 [Print] Switzerland
• PMID: 658860 (Publication Type: Journal Article)

Chemical References

• Thallium

Topics

• Animals
• Cerebellum (drug effects, ultrastructure)
• Injections, Intraperitoneal
• Male
• Microscopy, Electron
• Rats
• Thallium (administration & dosage, toxicity)