Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline.

Abstract

Feeding 4,4'-methylenebis(N,N-dimethyl)benzenamine [CAS: 101-61-1; 4,4'-methylenebis(N,N-dimethylaniline)] to inbred F344 rats increased the incidence of thyroid lesions (hyperplasia, adenomas, and carcinomas) in both sexes, especially in the female rats. 4,4'- Oxydianiline (CAS: 101-80-4) in the diet increased adenomas and carcinomas in the thyroid gland and neoplastic nodules and carcinomas in the liver of male and female F344 rats. In addition to increasing thyroid adenomas in females and hepatocellular adenomas or carcinomas in male and female B6C3F1 mice, 4,4'- oxydianiline increased adenomas of the harderian gland in male and female mice. 4,4'- Methylenedianiline (CAS: 101-77-9) in the drinking water increased neoplasms of the thyroid gland and liver in F344 rats and B6C3F1 mice.

• Authors: E K Weisburger, A S Murthy, H S Lilja, J C Lamb 4th
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 72 Issue 6 Pg. 1457-63 (Jun 1984) ISSN: 0027-8874 [Print] United States
• PMID: 6587162 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Aniline Compounds
• Carcinogens
• Coloring Agents
• Phenyl Ethers
• Polymers
• di-(4-aminophenyl)ether
• 4,4'-diaminodiphenylmethane

Topics

• Aniline Compounds
• Animals
• Carcinogens
• Coloring Agents (pharmacology)
• Dose-Response Relationship, Drug
• Female
• Male
• Mice
• Mice, Inbred C3H
• Mice, Inbred C57BL
• Neoplasms, Experimental (chemically induced, epidemiology)
• Phenyl Ethers
• Polymers (pharmacology)
• Rats
• Rats, Inbred F344
• Time Factors