[Toxicological properties of a cephedrine preparation].

Abstract

The antidepressant drug cephedrine experimentally displays a little acute and chronic toxicity, does not influence the development of allergic reaction in guinea pigs, changes but little the ECG and does not possess teratogenic and embryotoxic properties. When used in a subtoxic dose it is capable of causing dystrophic changes in individual neurons in the cortex and subcortical formations of the central nervous system, to delay the growth of fetuses, especially when administered during the second half of gestation.

• Authors: V G Pashinskiĭ, T M Vysokovskiĭ, Zh N Khlienko, A K Aref'eva, L F Ponomareva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1978 May-Jun Vol. 41 Issue 3 Pg. 345-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Toksikologicheskie svoĭstva preparata tsefedrina.
• PMID: 658386 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antidepressive Agents
• Nitriles
• Propanolamines
• Teratogens

Topics

• Animals
• Antidepressive Agents (immunology, toxicity)
• Central Nervous System (drug effects)
• Dogs
• Dose-Response Relationship, Drug
• Electrocardiography
• Female
• Fetus (drug effects)
• Guinea Pigs
• Lethal Dose 50
• Mice
• Nitriles (immunology, toxicity)
• Pregnancy
• Propanolamines (immunology, toxicity)
• Rats
• Teratogens
• Time Factors