Enhanced host resistance to transplantable murine lymphosarcoma in Swiss mice by combined immunostimulation with BCG and polyinosinic-polycytidylic acid.

Abstract

Combined immunostimulation with BCG and double-stranded polyinosinic-polycytidylic acid (poly I . poly C) was more effective than single-modality immunostimulation in suppressing tumor growth in inbred Swiss mice. BCG sensitization followed by administration of poly I . poly C on the day of tumor cell injection significantly prolonged the survival period against parental lymphosarcoma (LS) and its ascites variant (LS-A). BCG and poly I . poly C given together on the day of tumor cell injection suppressed only LS-A and not LS. BCG or poly I . poly C given alone did not result in tumor cures. Silica injection given 2 days before poly I . poly C injection completely abrogated the antitumor effect of sequential treatment with BCG and poly I . poly C. Silica treatment given on and beyond the day of poly I . poly C injection did not abrogate the antitumor effect. This observation indicated that intact macrophage effector function was essential at the time of tumor cell inoculation to obtain an effective antitumor action.

• Authors: T B Poduval, M Seshadri, K Sundaram
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 72 Issue 1 Pg. 139-43 (Jan 1984) ISSN: 0027-8874 [Print] United States
• PMID: 6582293 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• BCG Vaccine
• Poly I-C

Topics

• Adjuvants, Immunologic (administration & dosage)
• Animals
• BCG Vaccine (administration & dosage)
• Immunotherapy
• Lymphoma, Non-Hodgkin (immunology, therapy)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasm Transplantation
• Poly I-C (administration & dosage)