HLA-DR associations with Graves' disease in eastern Hungary.

Abstract

We have typed 196 patients with Graves' disease from eastern Hungary (an iodine-deficient region) for HLA-A, -B, and -C antigens and 80 of the same patients for HLA-DR antigens. Our data confirm the previously described association of HLA-B8 and DR3 with Graves' disease, particularly in patients with ophthalmopathy. We also describe several new findings: an increase in the prevalence of HLA-BW35, particularly in combination with B8, among patients with ophthalmopathy and a slight increase in the prevalence of B8, DR7 among patients with ophthalmopathy. These results support the concept that MHC-linked susceptibility to Graves' disease is dose-dependent. Our results do not confirm a report suggesting that the prevalence of HLA-DR5 is increased among patients without ophthalmopathy in iodine-deficient areas: we found that the prevalence of HLA-DR5 was slightly decreased among patients with Graves' disease, with and without ophthalmopathy, in comparison with controls.

• Authors: V Stenszky, L Kozma, C Balazs, N R Farid
• Journal: Clinical and investigative medicine. Medecine clinique et experimentale (Clin Invest Med) Vol. 6 Issue 3 Pg. 181-4 ( 1983) ISSN: 0147-958X [Print] Canada
• PMID: 6580983 (Publication Type: Journal Article)

Chemical References

• HLA-DR Antigens
• Histocompatibility Antigens Class II
• Iodine

Topics

• Eye Diseases (complications, immunology)
• Graves Disease (complications, immunology)
• HLA-DR Antigens
• Histocompatibility Antigens Class II (analysis)
• Humans
• Hungary
• Iodine (deficiency)