HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pharmacokinetics and tolerance of single intramuscular doses of cefotetan in normal Caucasian volunteers.

Abstract
Cefotetan, a third-generation cephalosporin, is extremely well tolerated by healthy Caucasian volunteers when given by intramuscular injection. It gives rise to prolonged high plasma antibiotic concentrations. Lignocaine (0.5%), when used as a diluent, had no effect on the pharmacokinetic parameters of cefotetan. Two grams of cefotetan given as the disodium salt 12 hourly by the intramuscular route gives plasma levels that are likely to be clinically effective in the treatment of infections due to a very wide range of Gram-positive and Gram-negative aerobes and anaerobes. The validity of this prediction however can only be established by subsequent clinical trials.
AuthorsR A Yates, I D Cockshott, H L Houghton, A Wardleworth, H Adam, R J Donnelly
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 11 Suppl Pg. 207-12 (Jan 1983) ISSN: 0305-7453 [Print] England
PMID6573318 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Cephalosporins
  • Cephamycins
  • Cefotetan
Topics
  • Adolescent
  • Adult
  • Anti-Bacterial Agents (metabolism)
  • Cefotetan
  • Cephalosporins (metabolism)
  • Cephamycins (adverse effects, metabolism)
  • Drug Tolerance
  • Humans
  • Injections, Intramuscular
  • Kinetics
  • Male
  • White People

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: