[State of the kallikrein-kinin system in blood from the heart ventricle in the dynamics of spontaneous hypertension in the rat].

Abstract

Estimations of prekallikrein and kallikrein inhibitor by means of TAME-esterase method and of the content of kininogen by biological procedure were carried out in blood plasma, isolated from right and left ventricles of heart, of rats with spontaneous hypertension, Okamoto-Aoki strain, and of the normotensive animals Wistar-Kyoto strain. The animals were 2=3 months, 6=8 months and 12=14 months old. Development of spontaneous hypertension was accompanied by an increase in the kallikrein-kinin system components studied. Content of prekallikrein and kininogen was higher in blood plasma from left heart ventricle than in blood from right ventricle, independently of the age of the rats, by 6=10% and 33=40%, respectively. Lung tissue was shown to carry out a definite reserve function in the compensatory increase of the kallikrein-kinin system potential under conditions of spontaneous hypertension.

• Authors: V V Karpitskiĭ
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1984 Sep-Oct Vol. 30 Issue 5 Pg. 110-3 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Sostoianie kallikrein-kininovoĭ sistemy krovi iz zheludochkov serdtsa v dinamike razvitiia spontannoĭ gipertenzii u krys.
• PMID: 6570384 (Publication Type: English Abstract, Journal Article)

Chemical References

• Kininogens
• Kinins
• Prekallikrein
• Kallikreins

Topics

• Age Factors
• Animals
• Blood Pressure
• Heart Ventricles
• Hypertension (blood, physiopathology)
• Kallikreins (blood)
• Kininogens (blood)
• Kinins (blood)
• Male
• Prekallikrein (analysis)
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY