DSIP reduces amphetamine-induced hyperthermia in mice.

Abstract

The effects of delta sleep-inducing peptide (DSIP) have not been fully determined. Besides sleep-inducing activities, effects on locomotor behavior, stress-reduction, and temperature-regulation have been published. It was reported that DSIP reversed the increase in temperature of rats injected at room temperature with 15 mg d-amphetamine per kg body weight. We examined this effect in mice with 9 different concentrations of DSIP in addition to D-Ala4-DSIP and an analog, DSIP-P, phosphorylated at the serine in position 7. A reduction of the increased temperature was observed in mice but not in rats. This effect was only significant after pretreatment with 0.1 and 150 nmol DSIP/kg, but not the other doses. D-Ala4-DSIP decreased the rise in temperature between 50-150 nmol/kg, but DSIP-P showed no such effect nor was DSIP able to significantly reduce the increase of temperature induced by the larger dose of 30 mg/kg d-amphetamine. A bell-shaped dose-response curve was found for D-Ala4-DSIP; for DSIP two active dose ranges were observed. Thus, complex dose-effect relationships seem to exist for DSIP (and perhaps its analogs) in thermoregulation.

• Authors: M V Graf, A J Kastin, D H Coy, J E Zadina
• Journal: Physiology & behavior (Physiol Behav) Vol. 33 Issue 2 Pg. 291-5 (Aug 1984) ISSN: 0031-9384 [Print] United States
• PMID: 6548818 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Oligopeptides
• Peptides
• delta-sleep-inducing peptide amine, Ala(4)-
• Delta Sleep-Inducing Peptide
• delta sleep-inducing peptide phosphate
• Dextroamphetamine

Topics

• Animals
• Body Temperature Regulation (drug effects)
• Delta Sleep-Inducing Peptide
• Dextroamphetamine (antagonists & inhibitors, pharmacology)
• Dose-Response Relationship, Drug
• Injections, Intraperitoneal
• Male
• Mice
• Mice, Inbred Strains
• Oligopeptides (pharmacology)
• Peptides (pharmacology)