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Behaviour of protein C inhibitor in intravascular coagulation and liver disease.

Abstract
We measured levels of protein C inhibitor in patients with disseminated intravascular coagulation (DIC) and liver disease using a functional assay. Levels in 24 normal subjects averaged 93% of the amount in normal pooled plasma, giving a normal range of 65 to 121%. Levels were below normal in 8 of 17 patients with DIC, in 4 of 19 patients with liver cirrhosis, and in 3 patients with acute hepatic necrosis. Levels were normal or elevated in 9 of 10 patients with cirrhosis and accelerated fibrinolysis, and in 6 patients receiving warfarin. We conclude that protein C inhibitor may be involved in regulation of protein C activity during pathologic activation of the hemostatic system (DIC). Decreased protein C inhibitor does not appear to contribute to the pathogenesis of accelerated fibrinolysis in liver disease. The liver may be the site of synthesis of protein C inhibitor.
AuthorsR B Francis Jr, W Thomas
JournalThrombosis and haemostasis (Thromb Haemost) Vol. 52 Issue 1 Pg. 71-4 (Aug 31 1984) ISSN: 0340-6245 [Print] Germany
PMID6548588 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Glycoproteins
  • Protein C
Topics
  • Disseminated Intravascular Coagulation (blood)
  • Glycoproteins (antagonists & inhibitors, blood)
  • Humans
  • Liver Cirrhosis (blood)
  • Liver Diseases (blood)
  • Necrosis
  • Protein C

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