Abstract |
In order to evaluate TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole), as a possible therapheutic compound to disseminated intravascular coagulation ( DIC), DIC model in rats was induced by the treatment of lambda-carrageenan according to the method of Sugiyama et al. with minor modification. Two hours after intraperitoneal injection of lambda-carrageenan, plasma fibrinogen decreased and platelet count, prothrombin time, serial thrombin time and plasma TXB2 prolonged or increased. By use of this model, the activities of TEI-4120, new antithrombotic compound, was evaluated compared with three other compounds, aspirin, warfarin and heparin. As a result, TEI-4120 is effective in this model. Combination therapy of TEI-4120 and warfarin is more effective than single administration of TEI-4120. The effect of combination therapy of TEI-4120 and warfarin is consistent with that of heparin. The above result suggests that TEI-4120 seems to be a promising compound to the therapy of DIC.
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Authors | H Wada, A Otsu, Y Takesue, K Sagara, T Makita |
Journal | Journal of pharmacobio-dynamics
(J Pharmacobiodyn)
Vol. 7
Issue 6
Pg. 385-91
(Jun 1984)
ISSN: 0386-846X [Print] Japan |
PMID | 6548260
(Publication Type: Journal Article)
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Chemical References |
- Fibrinolytic Agents
- Indoles
- Thromboxane B2
- Warfarin
- 3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole
- Carrageenan
- Heparin
- Aspirin
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Topics |
- Animals
- Aspirin
(pharmacology)
- Bleeding Time
- Carrageenan
- Disseminated Intravascular Coagulation
(blood, drug therapy, etiology)
- Fibrinolytic Agents
(therapeutic use)
- Hemodynamics
(drug effects)
- Heparin
(pharmacology)
- Indoles
(therapeutic use)
- Male
- Rats
- Rats, Inbred Strains
- Thromboxane B2
(antagonists & inhibitors)
- Warfarin
(pharmacology)
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