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Effect of TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methlindole) on carrageenan induced disseminated intravascular coagulation (DIC) in rats.

Abstract
In order to evaluate TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole), as a possible therapheutic compound to disseminated intravascular coagulation (DIC), DIC model in rats was induced by the treatment of lambda-carrageenan according to the method of Sugiyama et al. with minor modification. Two hours after intraperitoneal injection of lambda-carrageenan, plasma fibrinogen decreased and platelet count, prothrombin time, serial thrombin time and plasma TXB2 prolonged or increased. By use of this model, the activities of TEI-4120, new antithrombotic compound, was evaluated compared with three other compounds, aspirin, warfarin and heparin. As a result, TEI-4120 is effective in this model. Combination therapy of TEI-4120 and warfarin is more effective than single administration of TEI-4120. The effect of combination therapy of TEI-4120 and warfarin is consistent with that of heparin. The above result suggests that TEI-4120 seems to be a promising compound to the therapy of DIC.
AuthorsH Wada, A Otsu, Y Takesue, K Sagara, T Makita
JournalJournal of pharmacobio-dynamics (J Pharmacobiodyn) Vol. 7 Issue 6 Pg. 385-91 (Jun 1984) ISSN: 0386-846X [Print] Japan
PMID6548260 (Publication Type: Journal Article)
Chemical References
  • Fibrinolytic Agents
  • Indoles
  • Thromboxane B2
  • Warfarin
  • 3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole
  • Carrageenan
  • Heparin
  • Aspirin
Topics
  • Animals
  • Aspirin (pharmacology)
  • Bleeding Time
  • Carrageenan
  • Disseminated Intravascular Coagulation (blood, drug therapy, etiology)
  • Fibrinolytic Agents (therapeutic use)
  • Hemodynamics (drug effects)
  • Heparin (pharmacology)
  • Indoles (therapeutic use)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Thromboxane B2 (antagonists & inhibitors)
  • Warfarin (pharmacology)

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