In the search for new anticancer drugs. VII. Platinum complexes of diaziridines and azetidine.

Abstract

Three new diaziridine platinum(II) complexes (4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice. (formula; see text) Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 32 mg/kg for (3b), 190 at a dose of 32 mg/kg for (4a), 139 at a dose of 4 mg/kg for (4b), and 142 at a dose of 20 mg/kg for (4c).

• Authors: G Sosnovsky, J Lukszo
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 107 Issue 3 Pg. 217-20 ( 1984) ISSN: 0171-5216 [Print] Germany
• PMID: 6547443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Azetidines
• Azetines
• Aziridines
• Azirines
• Organoplatinum Compounds
• dimethylaziridine platinum(II)
• diethyldiaziridine platinum(II)
• azetidine platinum(II)

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, therapeutic use)
• Azetidines (chemical synthesis, therapeutic use)
• Azetines (chemical synthesis)
• Aziridines (chemical synthesis, therapeutic use)
• Azirines (chemical synthesis)
• Leukemia P388 (drug therapy)
• Magnetic Resonance Spectroscopy
• Male
• Mice
• Mice, Inbred Strains
• Organoplatinum Compounds (chemical synthesis, therapeutic use)
• Structure-Activity Relationship