Regulation of glucose metabolism in rat adrenal gland in alloxan-diabetes: the possible role of fructose 2,6-bisphosphate.

Abstract

The level of fructose 2,6-bisphosphate is markedly decreased in the rat V.renal gland in diabetes, falling to 23% of the control value. There is parallel decrease in the flux of 14C-labelled glucose through the glycolytic route and tricarboxylic acid cycle. Only minimal changes in hexokinase (EC 2.7.1.1.), a 22% decrease in Type I hexokinase of the soluble fraction, were observed, highlighting the probable significant involvement of fructose 2,6-bisphosphate in the regulation of glycolysis in the adrenal. In contrast, there was evidence for a marked rise in the flux of glucose through the pentose phosphate pathway, which may be linked to enhanced corticoid synthesis in the diabetic state.

• Authors: M Sochor, A M Gonzalez, P McLean
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 121 Issue 1 Pg. 8-13 (May 31 1984) ISSN: 0006-291X [Print] United States
• PMID: 6547341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fructosediphosphates
• Hexosediphosphates
• Isoenzymes
• Pentosephosphates
• fructose 2,6-diphosphate
• Hexokinase
• Glucose

Topics

• Adrenal Glands (metabolism)
• Animals
• Citric Acid Cycle
• Diabetes Mellitus, Experimental (metabolism)
• Fructosediphosphates (metabolism, physiology)
• Glucose (metabolism)
• Glycolysis
• Hexokinase (metabolism)
• Hexosediphosphates (physiology)
• Isoenzymes (metabolism)
• Male
• Pentosephosphates (metabolism)
• Rats
• Rats, Inbred Strains