Anthelmintic efficacy of avermectin B1a and dihydroavermectin B1a against ovine gastrointestinal nematodes in 1977.

Abstract

In a critical study, 40 female mixed-breed lambs with experimental infections of Cooperia spp, Trichostrongylus colubriformis, Ostertagia circumcincta, T axei, and Haemonchus contortus were allocated to 8 groups in 1977. Groups 1 and 5 served as controls. Groups 2 to 4 were treated orally with avermectin B1a at dosage levels of 25, 50, and 100 micrograms/kg of body weight, respectively. Groups 6 to 8 were given oral dihydroavermectin B1a at dosage levels of 50, 100, and 200 micrograms/kg, respectively. The lambs were euthanatized and necropsied 6 days after treatment. The compounds were greater than 99% effective at all dosage levels.

• Authors: K S Todd Jr, M E Mansfield, J A DiPietro
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 45 Issue 5 Pg. 976-7 (May 1984) ISSN: 0002-9645 [Print] United States
• PMID: 6547280 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Lactones
• avermectin B(1)a
• Ivermectin

Topics

• Animals
• Anthelmintics (administration & dosage, therapeutic use)
• Drug Evaluation (veterinary)
• Female
• Gastrointestinal Diseases (drug therapy, veterinary)
• Haemonchiasis (veterinary)
• Intestinal Diseases, Parasitic (drug therapy, veterinary)
• Ivermectin
• Lactones (administration & dosage, therapeutic use)
• Ostertagiasis (veterinary)
• Sheep
• Sheep Diseases (drug therapy)
• Trichostrongyloidiasis (drug therapy, veterinary)
• Trichostrongylosis (veterinary)