[Treatment of experimental metabolic alkalosis by sorbamine].

Abstract

A new infusion solution called alkamine has been developed for the treatment of metabolic alkalosis. It contains amino acids in the form of hydrochlorides (arginine, lysine and histidine hydrochlorides), potassium chloride and sorbit. The solution has been tested in anesthetized cats with experimental metabolic alkalosis induced by the injection of sodium hydrocarbonate solution. In control experiments without any therapy, a stable alkalytic shift of acid-base balance in the blood, a fall in the blood pressure, hypopotassemia and death of the animals within the first days were observed after experiments. The treatment of metabolic alkalosis by alkamine (25 experiments) entailed a complete correction of acid-base balance and hypopotassemia, stabilization of blood pressure and the survival of 23 out of the 25 animals. Alkamine solution has been approved for clinical trials by the Pharmacological Committee of the Ministry of Health of the USSR.

• Authors: I L Smirnova, T G Groznaia, V B Koziner, G Ia Rozenberg
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 97 Issue 2 Pg. 152-5 (Feb 1984) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Lechenie éksperimental'nogo metabolicheskogo alkaloza sorbaminom.
• PMID: 6546527 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Drug Combinations
• Sorbitol
• sorbamine
• Potassium

Topics

• Acid-Base Equilibrium (drug effects)
• Alkalosis (blood, drug therapy)
• Amino Acids (therapeutic use)
• Animals
• Cats
• Drug Combinations (therapeutic use)
• Infusions, Parenteral
• Potassium (blood)
• Sorbitol (therapeutic use)