Hypervitaminosis A toxicity in regular hemodialysis patients.

Abstract

A study has been made of possible inter-relationship between the plasma levels of vitamin A, retinol binding protein (RBP) prealbumin (PA), and biochemical parameters in 47 patients with end-stage renal failure maintained on regular dialysis treatment. The raised plasma concentrations of vitamin A, RBP and PA in patients were significantly different from those of normal controls. Plasma vitamin A levels were inversely correlated with Hct (r = -0.499), which was also significantly related to RBP/vitamin A ratio (r = 0.61). Plasma i-PTH and VLDL were inversely related to RBP/vitamin A and RBP/PA ratios. These findings suggest that raised plasma vitamin A levels in regular dialysis patients contribute to anemia and hypervitaminosis A toxicity. Vitamin A preparations should therefore not be given to patients on regular dialysis treatment.

• Authors: K Ono
• Journal: Transactions - American Society for Artificial Internal Organs (Trans Am Soc Artif Intern Organs) Vol. 30 Pg. 40-3 ( 1984) ISSN: 0066-0078 [Print] United States
• PMID: 6543480 (Publication Type: Journal Article)

Chemical References

• Prealbumin
• Retinol-Binding Proteins
• Retinol-Binding Proteins, Plasma
• Vitamin A

Topics

• Adult
• Aged
• Female
• Hematocrit
• Humans
• Hypervitaminosis A
• Kidney Failure, Chronic (blood, therapy)
• Male
• Middle Aged
• Prealbumin (metabolism)
• Renal Dialysis
• Retinol-Binding Proteins (metabolism)
• Retinol-Binding Proteins, Plasma
• Vitamin A (blood)