The effects of single and multiple doses of thiabendazole on growing and arrested stages of the rabbit stomach worm Obeliscoides cuniculi.

Abstract

Preliminary observations, using 5 rabbits carrying long-standing infections, indicated that single doses of thiabendazole were effective against adult O. cuniculi and that repeated doses may have had some effect on arrested larvae. A multiple dosing regime, consisting of 1 dose at 110 mg kg-1 body weight followed by 8 doses at 70 mg kg-1 body weight at 4-h intervals, was successful in removing 99.12% of developing worms and 86.04% of arrested larvae.

• Authors: A R Watkins, J O Slocombe, M A Fernando
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 16 Issue 3-4 Pg. 295-302 (Nov 1984) ISSN: 0304-4017 [Print] Netherlands
• PMID: 6542726 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Thiabendazole

Topics

• Animals
• Animals, Laboratory
• Dose-Response Relationship, Drug
• Female
• Larva (drug effects)
• Male
• Rabbits
• Species Specificity
• Thiabendazole (pharmacology, therapeutic use)
• Trichostrongyloidea (drug effects, growth & development)
• Trichostrongyloidiasis (drug therapy, parasitology, veterinary)