Citrinin mycotoxicosis in the rabbit: clinicopathological alterations.

Abstract

Citrinin, a nephrotoxic mycotoxin, was dissolved in 0.5 N-NaOH neutralized with HCl and given in a single oral dose of 120 mg/kg (Trial I) or 80 or 100 mg/kg (Trial II) to male New Zealand white rabbits weighing 2.0-2.7 kg. In Trial I, sequential measurements of clinicopathological parameters were made over a 24-hr period. Azotaemia and metabolic acidosis with haemoconcentration and hypokalaemia developed within 4-12 hr. In Trial II, clinicopathological and urinary parameters were measured daily for 7 days. Increased blood urea nitrogen and serum-creatine levels and decreased creatinine clearance indicated renal failure; these values were most abnormal on days 2-4, returning to normal or near normal by day 7 in rabbits that survived. Urine analysis indicated tubular dysfunction and necrosis with glucosuria, isosthenuria and cylindruria; most urinary parameters were normal by day 7.

• Authors: C Hanika, W W Carlton, G D Boon, J Tuite
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 22 Issue 12 Pg. 999-1008 (Dec 1984) ISSN: 0278-6915 [Print] England
• PMID: 6542549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzopyrans
• Bicarbonates
• Blood Glucose
• Blood Proteins
• Mycotoxins
• Citrinin
• Sodium
• Creatinine
• Potassium

Topics

• Animals
• Benzopyrans (pharmacology)
• Bicarbonates (blood)
• Blood Glucose (analysis)
• Blood Proteins (analysis)
• Blood Urea Nitrogen
• Citrinin (adverse effects, pharmacology)
• Creatinine (blood)
• Hematocrit
• Hydrogen-Ion Concentration
• Kidney (drug effects, pathology)
• Leukocyte Count
• Male
• Mycotoxins (adverse effects, pharmacology)
• Occult Blood
• Potassium (blood)
• Rabbits
• Rats
• Sodium (blood)