HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart.

Abstract
The effect of creatinol-O-phosphate (N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate, creatinolfosfate, Aplodan) pretreatment has been studied on the recovery of contractility of rat isolated heart after hypoxia or ischemia. In normoxia creatinol-O-phosphate (100 mumol/l) evoked a positive inotropic effect only when glucose was present in the physiological solution, it also evoked a slight negative chronotropic effect that was independent of glucose. When creatinol-O-phosphate was present during hypoxia, in the physiological solution, the recovery of the contraction after reoxygenation (in the absence of the drug) was improved in a dose-dependent manner. When creatinol-O-phosphate was present in the physiological solution before ischemia, the recovery of the contractility after reperfusion was higher than in controls; the presence of creatinol-O-phosphate during reperfusion after ischemia accelerated the recovery of contractility. The action of creatinol-O-phosphate on the recovery of cardiac contractility after ischemia was also observed in hearts partially protected with a cardioplegic solution. It is suggested that creatinol-O-phosphate could exert its cardioprotective effect by an action on anaerobic glycolysis.
AuthorsT Godfraind, M M Saleh
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 34 Issue 9 Pg. 968-72 ( 1984) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID6542374 (Publication Type: Journal Article)
Chemical References
  • creatinol phosphate
  • Glucose
  • Creatine
  • Oxygen
Topics
  • Animals
  • Creatine (analogs & derivatives, pharmacology)
  • Female
  • Glucose (pharmacology)
  • Heart (drug effects)
  • In Vitro Techniques
  • Myocardial Contraction (drug effects)
  • Oxygen (pharmacology)
  • Perfusion
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: