Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart.

The effect of creatinol-O-phosphate (N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate, creatinolfosfate, Aplodan) pretreatment has been studied on the recovery of contractility of rat isolated heart after hypoxia or ischemia. In normoxia creatinol-O-phosphate (100 mumol/l) evoked a positive inotropic effect only when glucose was present in the physiological solution, it also evoked a slight negative chronotropic effect that was independent of glucose. When creatinol-O-phosphate was present during hypoxia, in the physiological solution, the recovery of the contraction after reoxygenation (in the absence of the drug) was improved in a dose-dependent manner. When creatinol-O-phosphate was present in the physiological solution before ischemia, the recovery of the contractility after reperfusion was higher than in controls; the presence of creatinol-O-phosphate during reperfusion after ischemia accelerated the recovery of contractility. The action of creatinol-O-phosphate on the recovery of cardiac contractility after ischemia was also observed in hearts partially protected with a cardioplegic solution. It is suggested that creatinol-O-phosphate could exert its cardioprotective effect by an action on anaerobic glycolysis.
AuthorsT Godfraind, M M Saleh
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 34 Issue 9 Pg. 968-72 ( 1984) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID6542374 (Publication Type: Journal Article)
Chemical References
  • creatinol phosphate
  • Glucose
  • Creatine
  • Oxygen
  • Animals
  • Creatine (analogs & derivatives, pharmacology)
  • Female
  • Glucose (pharmacology)
  • Heart (drug effects)
  • In Vitro Techniques
  • Myocardial Contraction (drug effects)
  • Oxygen (pharmacology)
  • Perfusion
  • Rats
  • Rats, Inbred Strains
  • Time Factors

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