Studies of potential filaricides: Part 14--Activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis.

Abstract

The synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against Litomosoides carinii in Sigmodon hispidus and Dipetalonema viteae in Mastomys natalensis is reported. At an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult L. carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed chemoprophylactic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.

• Authors: R Rastogi, S Sharma, N Anand, A Dutta, N Fatma, R K Chatterjee, A B Sen
• Journal: Journal of helminthology (J Helminthol) Vol. 58 Issue 3 Pg. 251-4 (Sep 1984) ISSN: 0022-149X [Print] England
• PMID: 6542118 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Filaricides
• Piperazines
• 1-isobutoxycarbonyl-4-methylpiperazine

Topics

• Animals
• Anthelmintics (therapeutic use)
• Chemical Phenomena
• Chemistry
• Dipetalonema Infections (drug therapy, parasitology)
• Filariasis (drug therapy, parasitology)
• Filaricides (chemical synthesis, therapeutic use)
• Microfilariae
• Muridae
• Piperazines (chemical synthesis, therapeutic use)