Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol.

Abstract

o-Phenylphenol (OPP), a fungicide approved as a food additive in Japan, was given in pelleted diets at dietary levels of 0.156, 0.313, 0.625, 1.25 or 2.5% to groups of 11 or 12 F344/DuCrj rats of each sex for 13 wk, and 0.625, 1.25 or 2.5% to groups of 20-24 male F344/DuCrj rats for 91 wk. In the 13-wk study, transitional cell papillomas of the urinary bladder occurred in 6/12 (50%) of the male 1.25% group. In the 91-wk study, urinary bladder tumours appeared in 23/24 (96%) of the 1.25% and 4/23 (17%) of the 2.5% group. Among these tumours, transitional cell carcinomas were found in 20/23 (87%) of 1.25% and 2/4 (50%) of the 2.5% groups. A dose-related increase in the incidence of nephritic lesions was also observed in dosed rats in both the 13- and 91-wk study.

• Authors: K Hiraga, T Fujii
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 22 Issue 11 Pg. 865-70 (Nov 1984) ISSN: 0278-6915 [Print] England
• PMID: 6542051 (Publication Type: Journal Article)

Chemical References

• Biphenyl Compounds
• 2-phenylphenol

Topics

• Administration, Oral
• Animals
• Biphenyl Compounds (toxicity)
• Body Weight (drug effects)
• Female
• Humans
• Male
• Neoplasms, Experimental (pathology)
• Rats
• Rats, Inbred F344
• Urinary Bladder Diseases (chemically induced, pathology)
• Urinary Bladder Neoplasms (chemically induced, pathology)