Temporal changes in chromosome abnormality rate in human spontaneous abortions: evidence for an association between sex-chromosome monosomy and trisomy 16.

As part of a cytogenetic survey of human spontaneous abortions, the relative frequencies of different categories of chromosome abnormalities were evaluated for possible temporal changes. Three classes of chromosome abnormalities showed significant linear trends; sex-chromosome monosomy and tetraploidy decreased over the study period, while trisomy increased. The increase in trisomy was largely attributable to trisomy 16, which showed a two-fold increase over the duration of the study. The linear increase in trisomy 16 was inversely related to sex-chromosome monosomy. This effect was restricted to women over 30 yr of age and was most pronounced among Oriental women.
AuthorsT Hassold, C MacLean
JournalCytogenetics and cell genetics (Cytogenet Cell Genet) Vol. 38 Issue 3 Pg. 200-5 ( 1984) ISSN: 0301-0171 [Print] SWITZERLAND
PMID6541559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
  • Abortion, Spontaneous (genetics, pathology)
  • Adult
  • Chromosome Aberrations (epidemiology, pathology)
  • Chromosome Deletion
  • Chromosome Disorders
  • Chromosomes, Human, 16-18 (ultrastructure)
  • Continental Population Groups
  • Female
  • Humans
  • Karyotyping
  • Male
  • Monosomy
  • Polyploidy
  • Pregnancy
  • Sex Chromosome Aberrations (epidemiology, pathology)
  • Time Factors
  • Trisomy
  • X Chromosome (ultrastructure)
  • Y Chromosome (ultrastructure)

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