Olfactory neuroblastoma. Chemotherapy and radiotherapy for extensive disease.

Abstract

A patient with olfactory neuroblastoma had extensive involvement of the nasopharynx, sinuses and orbit, and cervical metastasis. After surgical biopsy and excision of metastatic disease, she was treated with chemotherapy: three cycles of high-dose cisplatin (100 mg/sq m) and infusion of fluorouracil (1 g/sq m/day for five days). Subsequent treatment included definitive radiation therapy followed by three additional cycles of chemotherapy. The patient is free of disease three years after initiating therapy. This case report demonstrates the potential efficacy of planned combined modality therapy, including early chemotherapy in the control of locally advanced, unresectable olfactory neuroblastoma.

• Authors: P L Weiden, C T Yarington Jr, R G Richardson
• Journal: Archives of otolaryngology (Chicago, Ill. : 1960) (Arch Otolaryngol) Vol. 110 Issue 11 Pg. 759-60 (Nov 1984) ISSN: 0003-9977 [Print] United States
• PMID: 6541469 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Female
• Fluorouracil (administration & dosage)
• Humans
• Middle Aged
• Nasopharyngeal Neoplasms (drug therapy, radiotherapy, therapy)
• Neuroectodermal Tumors, Primitive, Peripheral (drug therapy, radiotherapy, therapy)
• Radiotherapy Dosage
• Time Factors