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Pedigree study of familial Alzheimer disease.

Abstract
Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.
AuthorsD Powell, M F Folstein
JournalJournal of neurogenetics (J Neurogenet) Vol. 1 Issue 2 Pg. 189-97 (Apr 1984) ISSN: 0167-7063 [Print] England
PMID6536726 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Adult
  • Age Factors
  • Aged
  • Alzheimer Disease (genetics)
  • Female
  • Genes, Dominant
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Sex Factors

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