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Thermogenic properties of ciclazindol and mazindol in rodents.

Abstract
Ciclazindol, a noradrenaline (NA) uptake inhibitor originally introduced as an antidepressant, has recently been shown to produce weight loss in experimental animals and patients. Unlike CNS-stimulant anti-obesity drugs, such as amphetamine, ciclazindol may induce weight loss in animals by stimulating thermogenesis in brown adipose tissue (BAT), and it is known to stimulate resting metabolic rate (RMR) of rats and depress energetic efficiency. These effects can be achieved in the absence of overt CNS stimulation and with certain analogues of ciclazindol may be due to an exclusive peripheral action. Mazindol, a structural analogue of ciclazindol also produces an increase in RMR. However the increment is qualitatively and quantitatively different from that observed with ciclazindol and cannot be dissociated from central stimulant actions. In this report we examine some of the physiological and behavioural effects of ciclazindol and mazindol analogues in rats.
AuthorsM G Wyllie, A Fletcher, N J Rothwell, M J Stock
JournalInternational journal of obesity (Int J Obes) Vol. 8 Suppl 1 Pg. 85-92 ( 1984) England
PMID6534897 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Indoles
  • Pimozide
  • Mazindol
  • Amphetamine
  • ciclazindol
Topics
  • Amphetamine (pharmacology)
  • Animals
  • Behavior, Animal (drug effects)
  • Body Temperature Regulation (drug effects)
  • Body Weight (drug effects)
  • Energy Metabolism (drug effects)
  • Indoles (pharmacology)
  • Male
  • Mazindol (pharmacology)
  • Pimozide (pharmacology)
  • Rats
  • Rats, Inbred Strains

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