Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris.

Abstract

The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored. Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (1a) and hypoestestatin 2 (1b). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED50 = 10(-5) micrograms/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

• Authors: G R Pettit, A Goswami, G M Cragg, J M Schmidt, J C Zou
• Journal: Journal of natural products (J Nat Prod) 1984 Nov-Dec Vol. 47 Issue 6 Pg. 913-9 ISSN: 0163-3864 [Print] United States
• PMID: 6533268 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic
• Growth Inhibitors
• hypoestestatin 1
• hypoestestatin 2

Topics

• Alkaloids (isolation & purification, pharmacology)
• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Chemical Phenomena
• Chemistry
• Growth Inhibitors (pharmacology)
• Leukemia P388 (drug therapy)
• Mice