Comparative study on fucosylation of chicken liver and virus-induced hepatoma Mc-29.
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| Abstract |
Comparative studies on fucoprotein metabolism of chicken liver and hepatoma Mc-29 have been carried out and the following parameters were determined: the incorporation rate of [14C]fucose into hepatoma and liver total tissue homogenate, acid-soluble and acid-insoluble fractions, acid-soluble nucleotide fraction and into plasma-membrane acid-precipitable fraction; the activity of microsomal and plasma-membrane fucosyltransferase; the electrophoretic pattern of hepatoma and liver plasma-membrane proteins and the incorporation of [14C]fucose into the glycoprotein fractions in both plasma-membrane preparations. It was found that the labelling of hepatoma tissue homogenate and plasma membranes was higher than that of the same liver preparations 3 hr after the [14C]fucose injection. This finding was supported by a considerably elevated hepatoma fucosyltransferase activity. The labelling rate of numerous fucoproteins from hepatoma plasma membranes was greatly increased and some of the individual glycoprotein bands were labelled to a higher extent compared with liver. The data presented show specific alterations of fucose and fucoprotein metabolism which could be considered as a characteristic feature of chicken viral-induced hepatoma Mc-29.
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| Authors | M Antonova, S Ivanov, E Gavazova, H Chelibonova-Lorer |
| Journal | The International journal of biochemistry (Int J Biochem) Vol. 16 Issue 12 Pg. 1313-9 ( 1984) ISSN: 0020-711X [Print] England |
| PMID | 6530017 (Publication Type: Comparative Study, Journal Article) |
| Chemical References |
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