[Effect of synthetic regulators of radical reactions on the course of experimental silicosis].

Abstract

Therapeutic properties of N-oxide poly-1,2-ethylene piperidine (NO-PEP) as well as of free radical reaction inhibitors, bound with polymers by means of complex and covalent linkages, were studied in experimental silicosis. The preparations studied were used depending on the step of silicosis development as well as on the type of impairment in lipid peroxidation and the antioxidative activity (AOA) of lung lipids. The data obtained are discussed in relation to properties of the preparations used and to alterations in lipid peroxidation and AOA reactions found in silicosis. Use of immobilized physiologically active substances enabled to establish some principles in development of antisilicosis drugs.

• Authors: A S Ivanova, N G Puchkova, A V Nekrasov
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1984 Sep-Oct Vol. 30 Issue 5 Pg. 22-5 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Vliianie sinteticheskikh reguliatorov radikal'nykh reaktsiĭ na techenie éksperimental'nogo silikoza.
• PMID: 6528517 (Publication Type: English Abstract, Journal Article)

Chemical References

• Free Radicals
• Lipid Peroxides
• Piperidines
• poly(1,2-ethylenepiperidine) N-oxide

Topics

• Animals
• Fluorescence
• Free Radicals
• Lipid Peroxides (metabolism)
• Lung (metabolism)
• Male
• Piperidines (pharmacology, therapeutic use)
• Rats
• Rats, Inbred Strains
• Silicosis (drug therapy, metabolism)
• Time Factors