[Effects of the new cardiotonic agent TA-064: serial computer-assisted analyses of pressure-volume relations and online myocardial 02 consumption].

Abstract

UNLABELLED:

According to investigations conducted in Japan, TA-064 is a new cardiotonic agent, which is also effective orally. We analyzed computer-assisted alterations of pressure-volume relations serially and of MVO2 online (Bretschneider) during TA-064 influence in 16 patients with congestive cardiomyopathy: LV-function of 7 patients was only moderately decreased (group A) and in 9 patients massively (group B).

RESULTS:

1) TA-064, 8 micrograms/kg/min, i.v. had positive inotropic effects in both groups and induced mean maximal delta% changes at about the 5th minute of infusion as follows: LVSWI + 65% and 47%; DP/DTmax + 61% and 59%; LV-efficiency + 62% and 53%; MVO2 + 31% and + 11% (p less than 0.05). 2) TA-064, 20 mg p.o. induced serum levels (A: 23.8 +/- 12 and B: 26.4 +/- 20 ng/ml) corresponding to the effects with the dosages 1-2 micrograms/kg/min, i.v. (p greater than 0.05), thus implying that significant changes in LV-function require higher p.o. dosages. 3) TA-064 i.v. on the 6th day of exposure to the medication produced less LV-function improvement than on day 1 (p greater than 0.05).

CONCLUSIONS:

In both groups A and B TA-064 improves LV-function primarily via increased contractility, without toxic side effects. For a more complex definition of the efficiency and mechanism of cardiotonic agents, the validity and importance of using on-line MVO2 assessment and analysis of serial pressure-volume relations is stressed.

• Authors: J Thormann, W Kramer, M Kindler, H Neuss, H Bahawar, M Schlepper
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 73 Issue 12 Pg. 772-85 (Dec 1984) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Wirkungen des neuen Kardiotonikums TA-064: Serielle computerassistierte Analyse von Druck-Volumen-Beziehung und on-line MVO2-Bestimmung.
• PMID: 6523977 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cardiotonic Agents
• Ethanolamines
• denopamine

Topics

• Adult
• Blood Pressure (drug effects)
• Blood Volume (drug effects)
• Cardiac Output (drug effects)
• Cardiomyopathy, Dilated (drug therapy)
• Cardiotonic Agents (blood, therapeutic use)
• Computers
• Dose-Response Relationship, Drug
• Ethanolamines (blood, therapeutic use)
• Heart Failure (drug therapy)
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Myocardial Contraction (drug effects)
• Myocardium (metabolism)
• Online Systems (instrumentation)
• Oxygen Consumption (drug effects)